Ku-86 Polyclonal Antibody

X-ray repair cross-complementing protein 5 encoded by XRCC5 is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. XRCC5 functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity.

The Ku-86 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for use in various research applications. This antibody is produced by immunizing animals with a synthetic peptide corresponding to the C-terminal region of the human Ku-86 protein. The Ku-86 protein is a DNA-binding protein that plays a critical role in DNA repair and maintenance of genomic stability. The Ku-86 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. This antibody is suitable for use in both basic and clinical research, and it has the potential to contribute significantly to the understanding of DNA repair mechanisms and the development of novel therapeutic strategies for cancer and other diseases. The Ku-86 Polyclonal Antibody is available in various sizes and formats to meet the specific needs of researchers. With its high quality and reliability, this antibody is an excellent choice for researchers looking to advance their research in the field of DNA repair and genomic stability.