Ku-70 (Acetyl Lys542) Polyclonal Antibody

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

The Ku-70 (Acetyl Lys542) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Ku-70 protein acetylation at lysine 542. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The Ku-70 protein plays a crucial role in DNA repair and maintenance of genomic stability. Acetylation of lysine 542 has been shown to regulate the function of Ku-70, thereby influencing its involvement in DNA repair processes. The Ku-70 (Acetyl Lys542) Polyclonal Antibody specifically recognizes and binds to the acetylated form of Ku-70 at lysine 542, enabling researchers to investigate the impact of this post-translational modification on cellular processes.

This antibody exhibits exceptional sensitivity and specificity, ensuring accurate and reliable results. It has been extensively validated using various experimental approaches, including peptide blocking, knockdown/knockout validation, and positive control validation. The Ku-70 (Acetyl Lys542) Polyclonal Antibody demonstrates minimal cross-reactivity with other acetylated lysine residues, further enhancing its specificity.

With its superior performance characteristics, the Ku-70 (Acetyl Lys542) Polyclonal Antibody is an invaluable tool for researchers studying DNA repair mechanisms and cellular responses to DNA damage. Its versatility and reliability make it suitable for a wide range of applications, facilitating in-depth investigations into the role of Ku-70 acetylation in various biological processes.

Order the Ku-70 (Acetyl Lys542) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing DNA repair and maintenance of genomic stability.