IRP-1 Polyclonal Antibody

The protein encoded by ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The protein encoded by ACO1 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

The IRP-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IRP-1 protein in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and reliability.

The IRP-1 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the IRP-1 protein, making it an ideal choice for researchers and scientists working in the field of iron metabolism and related studies. With its superior sensitivity, this antibody enables accurate and precise measurement of IRP-1 protein levels, facilitating a deeper understanding of its role in cellular processes.

This antibody has been produced using state-of-the-art techniques and quality-controlled processes, ensuring batch-to-batch consistency and reproducibility. It has undergone extensive testing to guarantee its specificity and minimal cross-reactivity with other proteins, ensuring reliable and accurate results.

The IRP-1 Polyclonal Antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. Its versatility and robustness make it an indispensable tool for researchers seeking to investigate the expression and localization of IRP-1 protein in different biological systems.

In summary, the IRP-1 Polyclonal Antibody is a highly reliable and specific reagent that enables precise detection and quantification of IRP-1 protein. Its exceptional sensitivity and versatility make it an invaluable asset for researchers in the field of iron metabolism and related studies.