IL-8RBeta Polyclonal Antibody

The protein encoded by CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

The IL-8RBeta Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL-8RBeta protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

IL-8RBeta, also known as interleukin-8 receptor beta, is a crucial component of the IL-8 receptor complex. It plays a pivotal role in mediating the biological activities of IL-8, a pro-inflammatory chemokine involved in immune responses and inflammatory processes. The IL-8RBeta Polyclonal Antibody specifically recognizes and binds to IL-8RBeta, enabling accurate measurement and analysis of its expression levels.

This antibody exhibits outstanding specificity, exhibiting minimal cross-reactivity with other related proteins, ensuring precise and reliable results. It has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence, demonstrating its versatility and suitability for diverse applications.

The IL-8RBeta Polyclonal Antibody is manufactured to the highest quality standards, employing stringent quality control measures throughout the production process. It is produced using state-of-the-art recombinant DNA technology and purified using advanced chromatographic techniques, ensuring high purity and batch-to-batch consistency.

With its exceptional sensitivity and specificity, the IL-8RBeta Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of IL-8RBeta in various biological processes. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications.

In summary, the IL-8RBeta Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of IL-8RBeta protein. Its exceptional performance, versatility, and stringent quality control measures make it an invaluable asset for researchers in the field of immunology and inflammation.