IL-12RBeta1 Polyclonal Antibody

The interleukin 12 receptor subunit beta 1 encoded by IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

The IL-12RBeta1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of IL-12RBeta1 protein in various biological samples. This antibody has been extensively validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

IL-12RBeta1, also known as interleukin-12 receptor subunit beta-1, plays a crucial role in the immune response by mediating the signaling of interleukin-12 (IL-12), a key cytokine involved in the regulation of T-cell differentiation and activation. Dysregulation of IL-12RBeta1 has been implicated in various immune-related disorders, making it an important target for research and therapeutic interventions.

The IL-12RBeta1 Polyclonal Antibody has been meticulously developed using high-quality immunogens and state-of-the-art production techniques. It exhibits exceptional specificity, displaying minimal cross-reactivity with other related proteins, ensuring accurate and reliable results. Furthermore, this antibody demonstrates excellent sensitivity, enabling the detection of low levels of IL-12RBeta1 protein in even the most challenging samples.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a variety of sizes to accommodate different experimental needs. Each batch of the IL-12RBeta1 Polyclonal Antibody undergoes rigorous quality control testing to ensure consistent performance and batch-to-batch reproducibility.

In summary, the IL-12RBeta1 Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of IL-12RBeta1 protein. Its exceptional performance in various applications, combined with its superior sensitivity and specificity, makes it an invaluable asset for researchers and clinicians studying the role of IL-12RBeta1 in immune-related disorders.