IL-12B Polyclonal Antibody

IL12B encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.

The IL-12B Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL-12B protein in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards IL-12B.

IL-12B, also known as interleukin-12 subunit beta, plays a crucial role in the immune response by promoting the differentiation of T cells into Th1 cells. It is involved in the regulation of various immune processes, including the activation of natural killer cells and the production of interferon-gamma.

The IL-12B Polyclonal Antibody is validated for use in various applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). It exhibits excellent performance in detecting IL-12B protein in a wide range of species, including human, mouse, and rat.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure its reliability and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is provided in various sizes to meet the diverse needs of researchers.

With its exceptional sensitivity and specificity, the IL-12B Polyclonal Antibody is an indispensable tool for studying the role of IL-12B in immune responses, inflammation, and various disease states. Its reliable performance and ease of use make it an ideal choice for researchers in the fields of immunology, molecular biology, and biomedical research.