IL-12A p35 Polyclonal Antibody

IL12A encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

The IL-12A p35 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL-12A p35 protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

IL-12A p35 is a subunit of the interleukin-12 (IL-12) cytokine, which plays a crucial role in the regulation of immune responses. It is primarily produced by activated antigen-presenting cells and acts as a key mediator in the differentiation of T-helper 1 (Th1) cells. IL-12A p35 is involved in the activation of natural killer (NK) cells and the production of interferon-gamma (IFN-γ), which are essential for the elimination of intracellular pathogens.

The IL-12A p35 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into existing laboratory protocols. The IL-12A p35 Polyclonal Antibody is compatible with a wide range of detection systems and can be used in both research and clinical applications.

With its exceptional performance characteristics and reliable results, the IL-12A p35 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of IL-12A p35 in immune responses and its potential as a therapeutic target.