IL-10R Alpha Polyclonal Antibody

Interleukin-10 receptor subunit alpha encoded by IL10RA is a receptor for interleukin 10. Interleukin-10 receptor subunit alpha is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

The IL-10R Alpha Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of IL-10R Alpha protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

IL-10R Alpha, also known as interleukin-10 receptor subunit alpha, plays a crucial role in the regulation of immune responses and inflammation. It is a transmembrane protein that is expressed on various immune cells, including T cells, B cells, and macrophages. By binding to its ligand, IL-10, IL-10R Alpha initiates downstream signaling pathways that modulate immune cell activation and cytokine production.

The IL-10R Alpha Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and flow cytometry. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into laboratory workflows. The IL-10R Alpha Polyclonal Antibody is compatible with a wide range of detection systems and can be used in both research and clinical applications.

In summary, the IL-10R Alpha Polyclonal Antibody is a highly reliable and versatile tool for the detection and quantification of IL-10R Alpha protein. Its exceptional specificity, sensitivity, and ease of use make it an essential component in immunological research and diagnostic applications.