IDH1 Polyclonal Antibody

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

The IDH1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of isocitrate dehydrogenase 1 (IDH1) protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

The IDH1 Polyclonal Antibody exhibits a high affinity towards IDH1, enabling accurate and precise identification of this crucial protein. It has been extensively validated through rigorous testing to guarantee its specificity and sensitivity, making it an ideal choice for researchers and scientists working in the field of molecular biology and related disciplines.

This antibody is produced using state-of-the-art recombinant technology, ensuring batch-to-batch consistency and minimizing any potential variability. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution procedures.

The IDH1 Polyclonal Antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been optimized for use in both human and animal samples, providing versatility and flexibility for a wide range of experimental designs.

With its exceptional performance, reliability, and ease of use, the IDH1 Polyclonal Antibody is an indispensable tool for researchers seeking to investigate the role of IDH1 in cellular processes and disease mechanisms. Trust in its quality and precision to advance your scientific endeavors and contribute to the advancement of knowledge in the field.