ICAD Polyclonal Antibody

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for DFFA.

The ICAD Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of ICAD protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

The ICAD Polyclonal Antibody exhibits a high affinity towards the ICAD protein, enabling accurate and precise detection even at low concentrations. It has been extensively validated through rigorous testing to guarantee consistent and reproducible results.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is compatible with various sample types, such as cell lysates, tissue extracts, and serum.

The ICAD Polyclonal Antibody is manufactured under strict quality control standards to ensure batch-to-batch consistency and optimal performance. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation steps.

With its exceptional specificity and sensitivity, the ICAD Polyclonal Antibody is an indispensable tool for researchers and scientists working in the field of apoptosis and DNA fragmentation. It provides valuable insights into the mechanisms underlying cell death and DNA damage, facilitating advancements in various areas of biomedical research.

Choose the ICAD Polyclonal Antibody for reliable and accurate detection of ICAD protein, and unlock new possibilities in your research endeavors.