Huntingtin Polyclonal Antibody

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13. kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10. kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

The Huntingtin Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of huntingtin protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Huntingtin Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the huntingtin protein without cross-reactivity to other proteins. This feature enables accurate and precise detection of huntingtin in complex biological matrices. The antibody's high sensitivity allows for the detection of low levels of huntingtin, making it an ideal choice for both qualitative and quantitative analysis.

This antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. The Huntingtin Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids.

With its exceptional performance characteristics, the Huntingtin Polyclonal Antibody is an indispensable tool for researchers studying the role of huntingtin in various biological processes and diseases. Its reliable and accurate detection capabilities make it an invaluable asset in the field of neurodegenerative disorders, particularly Huntington's disease research.

Choose the Huntingtin Polyclonal Antibody for its exceptional specificity, sensitivity, and reliability, and unlock new insights into the biology and pathology of huntingtin protein.