HUNK Polyclonal Antibody

The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha and CAB39.

The HUNK Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of HUNK protein expression in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure exceptional performance and reliability in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The HUNK Polyclonal Antibody exhibits exceptional affinity and selectivity towards the HUNK protein, enabling accurate and precise detection even at low expression levels. Its high sensitivity allows for the detection of subtle changes in HUNK protein expression, making it an invaluable tool for researchers studying the role of HUNK in various cellular processes and disease states.

This antibody has been produced using state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. It has undergone extensive quality control measures to guarantee optimal performance, including validation in multiple cell lines and tissues known to express HUNK. Furthermore, the HUNK Polyclonal Antibody has been validated for use in both human and animal samples, providing versatility and flexibility for a wide range of research applications.

The HUNK Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its user-friendly format allows for easy integration into existing laboratory protocols, saving valuable time and resources. Additionally, this antibody exhibits excellent stability, ensuring long-term storage without compromising its performance.

In summary, the HUNK Polyclonal Antibody is a highly reliable and efficient tool for the detection and quantification of HUNK protein expression. Its exceptional sensitivity, specificity, and versatility make it an indispensable asset for researchers in the fields of molecular biology, biochemistry, and biomedical research.