HoxB4 Polyclonal Antibody

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. Homeobox protein Hox-B4 functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

The HoxB4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of HoxB4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the HoxB4 protein. The HoxB4 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The HoxB4 protein is a transcription factor that plays a critical role in the regulation of hematopoietic stem cell self-renewal and differentiation. Dysregulation of HoxB4 expression has been implicated in various hematological disorders, including leukemia and lymphoma. Therefore, the HoxB4 Polyclonal Antibody is an essential tool for researchers studying the role of HoxB4 in hematopoiesis and its potential as a therapeutic target for hematological disorders.

The HoxB4 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using protein A chromatography. This antibody is provided in a liquid format and can be stored at -20°C for long-term storage. The HoxB4 Polyclonal Antibody is available in various sizes to meet the needs of different applications and experimental designs.

In summary, the HoxB4 Polyclonal Antibody is a highly specific and sensitive antibody that is essential for researchers studying the role of HoxB4 in hematopoiesis and its potential as a therapeutic target for hematological disorders. This antibody is extensively validated and available in various sizes to meet the needs of different applications and experimental designs.