Histone H4 Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H4 Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of histone H4 protein in various biological samples. This antibody has been extensively validated and exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Histone H4 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It is derived from a host animal that has been immunized with a synthetic peptide corresponding to a specific region of the histone H4 protein. This antibody recognizes both the unmodified and modified forms of histone H4, making it an ideal choice for studying post-translational modifications and their functional implications.

With its superior sensitivity and specificity, the Histone H4 Polyclonal Antibody enables accurate and reliable detection of histone H4 protein in even low abundance samples. Its exceptional performance ensures minimal background noise and high signal-to-noise ratio, allowing for precise quantification and analysis.

The Histone H4 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy customization and optimization of experimental conditions. This antibody has been extensively tested and validated in various cell lines and tissues, ensuring its reliability and reproducibility.

In summary, the Histone H4 Polyclonal Antibody is a highly reliable and versatile tool for the detection and analysis of histone H4 protein. Its exceptional sensitivity, specificity, and performance make it an essential reagent for researchers studying epigenetics, chromatin biology, and gene regulation.