Histone H4 Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H4 Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of histone H4 protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

Histone H4 is a core histone protein that plays a crucial role in chromatin structure and gene regulation. It is involved in the packaging of DNA into nucleosomes, which are the basic units of chromatin. The modification of histone H4, such as acetylation, methylation, and phosphorylation, has been implicated in various cellular processes, including transcriptional activation and repression.

The Histone H4 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other histone proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The antibody is stable and can be stored at -20°C for long-term storage.

In summary, the Histone H4 Polyclonal Antibody is a valuable tool for researchers studying histone biology and epigenetics. Its high specificity, sensitivity, and ease of use make it an essential component in various research applications.