Histone H4 (Di Methyl Lys59) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from HIST4H4 lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Di Methyl Lys59) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Histone H4 protein modifications. This antibody is produced using advanced immunization techniques, resulting in a high affinity and specificity towards the di-methylated lysine 59 residue of Histone H4.

Histone H4 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. The di-methylation of lysine 59 on Histone H4 has been implicated in various biological processes, including transcriptional regulation, DNA repair, and cell cycle progression.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other histone modifications, ensuring accurate and reliable results.

With its high sensitivity and specificity, the Histone H4 (Di Methyl Lys59) Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin biology, and gene regulation. Its superior performance and consistent results make it an ideal choice for both basic research and clinical applications.