Histone H4 (Acetyl Lys91) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from HIST4H4 lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Acetyl Lys91) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Histone H4 protein acetylated at Lysine 91. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H4 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 91 on Histone H4 has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the detection and quantification of Histone H4 acetylated at Lysine 91 is of great importance in understanding the underlying mechanisms of these processes.

The Histone H4 (Acetyl Lys91) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering.

In summary, the Histone H4 (Acetyl Lys91) Polyclonal Antibody is an indispensable tool for researchers studying histone modifications and their impact on gene expression and cellular processes. Its high specificity, sensitivity, and ease of use make it an ideal choice for a wide range of applications in molecular biology and epigenetics research.