Histone H4 (Acetyl Lys16) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from HIST4H4 lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Acetyl Lys16) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of acetylated lysine 16 on histone H4. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

Histone H4 is a core histone protein that plays a crucial role in chromatin structure and gene regulation. Acetylation of lysine 16 on histone H4 has been implicated in various biological processes, including transcriptional activation and DNA repair. The Histone H4 (Acetyl Lys16) Polyclonal Antibody specifically recognizes and binds to acetylated lysine 16 on histone H4, allowing for the precise detection and quantification of this modification.

This antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation. It exhibits high specificity and sensitivity, enabling accurate and reliable results. The antibody is supplied as a purified and concentrated solution, ensuring ease of use and long-term stability.

In summary, the Histone H4 (Acetyl Lys16) Polyclonal Antibody is a valuable tool for researchers studying histone modifications and their role in gene regulation. Its high specificity, sensitivity, and reliability make it an essential component of any laboratory involved in epigenetics research.