Histone H4 (Acetyl Lys12) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Acetyl Lys12) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of acetylated Lysine 12 on Histone H4. This antibody has been rigorously tested and validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

Histone H4 is a core histone protein that plays a crucial role in chromatin structure and gene regulation. Acetylation of Lysine 12 on Histone H4 has been implicated in various biological processes, including transcriptional activation and DNA repair. The Histone H4 (Acetyl Lys12) Polyclonal Antibody recognizes and binds specifically to the acetylated form of Lysine 12 on Histone H4, allowing for the precise detection and quantification of this post-translational modification.

This antibody has been produced using high-quality materials and state-of-the-art techniques to ensure optimal performance and reliability. It exhibits high affinity and specificity towards acetylated Lysine 12 on Histone H4, enabling accurate and reproducible results. The antibody has been extensively characterized and validated using a variety of experimental approaches, ensuring its suitability for a wide range of research applications.

The Histone H4 (Acetyl Lys12) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody has been optimized for use in various experimental conditions, including different sample types and species, ensuring its versatility and adaptability to diverse research needs.

In summary, the Histone H4 (Acetyl Lys12) Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of acetylated Lysine 12 on Histone H4. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers studying chromatin structure, gene regulation, and epigenetics.