Histone H4 (Acetyl Lys12) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from HIST4H4 lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Acetyl Lys12) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 12 residue on Histone H4. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H4 is a core histone protein that plays a crucial role in chromatin structure and gene regulation. Acetylation of Lysine 12 on Histone H4 has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the detection and quantification of acetylated Lysine 12 on Histone H4 is of great importance in understanding the epigenetic regulation of gene expression.

The Histone H4 (Acetyl Lys12) Polyclonal Antibody exhibits excellent performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been validated for use in multiple species, ensuring its versatility and reliability in different experimental settings.

With its high sensitivity and specificity, the Histone H4 (Acetyl Lys12) Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin remodeling, and gene regulation. Its superior performance and consistent results make it an ideal choice for both basic research and clinical applications.

Order the Histone H4 (Acetyl Lys12) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of gene expression and epigenetic regulation.