Histone H3 Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

Histone H3 is a crucial component of chromatin, playing a vital role in gene regulation and chromosomal stability. The Histone H3 Polyclonal Antibody recognizes and binds to the N-terminal tail of histone H3, allowing for the identification and quantification of this protein in a wide range of applications, including immunohistochemistry, western blotting, and chromatin immunoprecipitation.

With its exceptional sensitivity and specificity, this antibody enables researchers to investigate the dynamic changes in histone H3 modifications, providing valuable insights into epigenetic regulation and its impact on cellular processes. Its versatility and reliability make it an indispensable tool for studying histone H3 biology and its implications in various disease states, such as cancer and neurodegenerative disorders.

The Histone H3 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue sections, and purified histones. Furthermore, it exhibits excellent performance across multiple species, including human, mouse, and rat, ensuring its applicability in diverse research settings.

In summary, the Histone H3 Polyclonal Antibody offers researchers a reliable and efficient means to investigate the role of histone H3 in gene regulation and chromatin dynamics. Its high specificity, sensitivity, and compatibility with various techniques and sample types make it an invaluable tool for advancing our understanding of epigenetic mechanisms and their implications in health and disease.