Histone H3 Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

Histone H3 is a crucial component of chromatin, playing a vital role in gene regulation and chromosomal stability. This polyclonal antibody recognizes multiple epitopes of histone H3, enabling comprehensive detection and analysis of its various post-translational modifications, including acetylation, methylation, phosphorylation, and ubiquitination.

The Histone H3 Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation. Its high affinity and low background ensure accurate and reliable results, even in complex biological samples.

This antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with various detection systems and can be used in both manual and automated protocols, providing flexibility and convenience for researchers.

With its superior performance and versatility, the Histone H3 Polyclonal Antibody is an indispensable tool for studying histone H3 biology and unraveling the intricate mechanisms of epigenetic regulation. Trust in its quality and reliability to advance your research in the fields of chromatin biology, cancer research, and developmental biology.