Histone H3 (Tri Methyl Lys27) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A (histone cluster 1 H3 family member a) is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Tri Methyl Lys27) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of histone H3 protein modifications. This antibody is designed to specifically recognize and bind to the tri methylated lysine 27 residue on histone H3, allowing for the precise identification and quantification of this specific modification.

The Histone H3 (Tri Methyl Lys27) Polyclonal Antibody is produced using advanced immunization techniques, resulting in a high affinity and specificity for the target epitope. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation.

This antibody offers exceptional performance in detecting and quantifying histone H3 tri methyl lysine 27 modifications in a wide range of sample types, including cell lysates, tissue extracts, and chromatin preparations. Its superior sensitivity and specificity ensure accurate and reliable results, making it an indispensable tool for researchers studying epigenetic modifications and their role in gene regulation and disease development.

The Histone H3 (Tri Methyl Lys27) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and format, allowing for easy handling and storage. Each batch of antibody is rigorously quality controlled to ensure consistent performance and reliability.

In summary, the Histone H3 (Tri Methyl Lys27) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of histone H3 protein modifications. Its exceptional performance, reliability, and ease of use make it an essential reagent for researchers in the field of epigenetics and chromatin biology.