Histone H3 (Mono Methyl Lys80) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Mono Methyl Lys80) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 mono-methylated at lysine 80. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target antigen.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Lysine 80 methylation of histone H3 has been implicated in various biological processes, including transcriptional regulation, DNA repair, and cell cycle progression. Therefore, the ability to accurately detect and quantify this modification is of utmost importance in understanding the underlying mechanisms of these processes.

The Histone H3 (Mono Methyl Lys80) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling precise detection and quantification of histone H3 mono-methylated at lysine 80. It has been extensively validated for various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). This antibody demonstrates minimal cross-reactivity with other histone modifications, ensuring reliable and accurate results.

Furthermore, the Histone H3 (Mono Methyl Lys80) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent performance and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation.

In summary, the Histone H3 (Mono Methyl Lys80) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of histone H3 mono-methylated at lysine 80. Its exceptional sensitivity and specificity, along with its versatility in various applications, make it an invaluable asset for researchers studying epigenetic modifications and their role in cellular processes.