Histone H3 (Mono Methyl Lys10) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Mono Methyl Lys10) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 mono-methylated at lysine 10. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target antigen.

Histone H3 is a crucial component of chromatin, playing a vital role in gene regulation and chromatin structure. Lysine 10 mono-methylation of histone H3 has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify this modification is of utmost importance in understanding the underlying mechanisms of these processes.

The Histone H3 (Mono Methyl Lys10) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation. It exhibits exceptional sensitivity and specificity, enabling reliable and reproducible results.

This antibody is manufactured using high-quality materials and stringent quality control measures to ensure batch-to-batch consistency and reliability. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

In summary, the Histone H3 (Mono Methyl Lys10) Polyclonal Antibody is a valuable tool for researchers studying histone modifications and their functional implications. Its high specificity, sensitivity, and versatility make it an ideal choice for various applications in the field of epigenetics and chromatin biology.