Histone H3 (Acetyl Lys79) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Acetyl Lys79) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 79 residue on Histone H3. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 79 on Histone H3 has been implicated in various biological processes, including transcriptional activation and chromatin remodeling. Therefore, the detection and quantification of acetylated Lysine 79 are of great importance in understanding the epigenetic regulation of gene expression.

The Histone H3 (Acetyl Lys79) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of acetylated Lysine 79 on Histone H3. It has been extensively validated for various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation.

This antibody is produced using high-quality materials and undergoes rigorous quality control procedures to ensure consistent performance and reliability. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

In summary, the Histone H3 (Acetyl Lys79) Polyclonal Antibody is a valuable tool for researchers studying epigenetic modifications and gene regulation. Its high specificity, sensitivity, and versatility make it an ideal choice for various applications in molecular biology and biomedical research.