Histone H3 (Acetyl Lys4) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Acetyl Lys4) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 4 on Histone H3 proteins. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 4 on Histone H3 has been associated with active gene transcription and is therefore of great interest in various research fields, including epigenetics and cancer biology.

The Histone H3 (Acetyl Lys4) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

With its superior quality and performance, the Histone H3 (Acetyl Lys4) Polyclonal Antibody is an indispensable tool for researchers studying histone modifications and their impact on gene expression and cellular processes.