Histone H3 (Acetyl Lys36) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Acetyl Lys36) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 36 on Histone H3. This antibody is produced using a polyclonal approach, ensuring a high affinity and specificity towards the target antigen.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 36 on Histone H3 has been implicated in various biological processes, including transcriptional activation and DNA repair.

The Histone H3 (Acetyl Lys36) Polyclonal Antibody is rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of acetylated Lysine 36 on Histone H3 in diverse sample types.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure consistent and reproducible results. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

The Histone H3 (Acetyl Lys36) Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin remodeling, and gene regulation. Its high specificity and sensitivity make it an ideal choice for investigating the role of acetylated Lysine 36 on Histone H3 in various biological processes and disease states.