Histone H3 (Acetyl Lys18) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Acetyl Lys18) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 18 residue on Histone H3. This antibody is produced using a polyclonal approach, ensuring a diverse population of antibodies that recognize the target epitope with high affinity and specificity.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 18 on Histone H3 has been implicated in various biological processes, including transcriptional activation and chromatin remodeling. Therefore, the detection and quantification of acetylated Lysine 18 on Histone H3 are of great importance in understanding the underlying mechanisms of gene expression and epigenetic regulation.

The Histone H3 (Acetyl Lys18) Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal tool for various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). It has been extensively validated in multiple experimental settings, ensuring reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The Histone H3 (Acetyl Lys18) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent performance and batch-to-batch reproducibility.

In summary, the Histone H3 (Acetyl Lys18) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of acetylated Lysine 18 on Histone H3. Its exceptional sensitivity and versatility make it an invaluable asset for researchers studying gene regulation, epigenetics, and chromatin biology.