Histone H3 (Acetyl Lys123) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST1H3A lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Acetyl Lys123) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Histone H3 protein acetylated at Lysine 123. This antibody is produced using a polyclonal approach, ensuring a high affinity and specificity towards the target protein.

Histone H3 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 123 on Histone H3 has been implicated in various biological processes, including transcriptional activation and chromatin remodeling.

This polyclonal antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of Histone H3 acetylated at Lysine 123 in various biological samples.

The Histone H3 (Acetyl Lys123) Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure consistent and reliable results. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

Researchers and scientists in the fields of epigenetics, chromatin biology, and gene regulation will greatly benefit from the use of this antibody in their studies. Its high specificity and sensitivity make it an invaluable tool for investigating the role of Histone H3 acetylation in various biological processes.

In summary, the Histone H3 (Acetyl Lys123) Polyclonal Antibody is a reliable and efficient reagent for the detection and quantification of Histone H3 protein acetylated at Lysine 123. Its high specificity, sensitivity, and compatibility with various applications make it an essential tool for researchers aiming to unravel the intricate mechanisms of gene regulation and chromatin remodeling.