Histone H2B (Acetyl Lys5) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H2BA is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from HIST1H2BA contain a palindromic termination element.

The Histone H2B (Acetyl Lys5) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 5 on Histone H2B. This antibody is produced through a rigorous process of immunization and purification, ensuring high affinity and specificity towards the target antigen.

Histone H2B is a crucial component of the nucleosome, playing a vital role in chromatin structure and gene regulation. Acetylation of Lysine 5 on Histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify this modification is of utmost importance in understanding the underlying mechanisms of gene expression and chromatin dynamics.

The Histone H2B (Acetyl Lys5) Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its high sensitivity and specificity enable reliable and reproducible results, making it an indispensable tool for researchers in the fields of epigenetics, chromatin biology, and gene regulation.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been extensively validated in various experimental conditions and species, ensuring consistent and reliable performance. Additionally, it is provided in a convenient size, allowing for multiple experiments without compromising quality.

In summary, the Histone H2B (Acetyl Lys5) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of acetylated Lysine 5 on Histone H2B. Its exceptional performance and versatility make it an essential asset for researchers aiming to unravel the intricate mechanisms of gene regulation and chromatin dynamics.