Histone H2B (Acetyl Lys23) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H2BA is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from HIST1H2BA contain a palindromic termination element.

The Histone H2B (Acetyl Lys23) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 23 residue on Histone H2B. This antibody is produced through a rigorous process of immunization and purification, ensuring high affinity and specificity towards the target antigen.

Histone H2B is a crucial component of the nucleosome, playing a vital role in chromatin structure and gene regulation. Acetylation of Lysine 23 on Histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the detection and quantification of this acetylation mark are of great importance in understanding the underlying mechanisms of gene expression and chromatin dynamics.

The Histone H2B (Acetyl Lys23) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results. This antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified histones.

With its high specificity and sensitivity, the Histone H2B (Acetyl Lys23) Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin biology, and gene regulation. Its reliable performance and versatility make it an ideal choice for both basic research and clinical applications.