Histone H2B (Acetyl Lys12) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H2BA is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from HIST1H2BA contain a palindromic termination element.

The Histone H2B (Acetyl Lys12) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 12 residue on Histone H2B. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H2B is a crucial component of the nucleosome, playing a vital role in chromatin structure and gene regulation. Acetylation of Lysine 12 on Histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the detection and quantification of acetylated Lysine 12 residue on Histone H2B is of great importance in understanding the epigenetic regulation of gene expression.

The Histone H2B (Acetyl Lys12) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

With its high-quality formulation and optimized protocols, this antibody offers researchers a valuable tool for investigating the role of acetylated Lysine 12 on Histone H2B in various biological processes. Its superior performance and reliability make it an ideal choice for both basic research and clinical applications.

Order the Histone H2B (Acetyl Lys12) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of gene regulation and epigenetic modifications.