Histone H2A.Z Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

The Histone H2A.Z Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H2A.Z protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

Histone H2A.Z is a variant of the core histone H2A protein and plays a crucial role in chromatin remodeling and gene expression regulation. It is involved in various biological processes, including transcriptional activation, DNA repair, and genome stability. The Histone H2A.Z Polyclonal Antibody recognizes and binds specifically to the H2A.Z protein, enabling researchers to investigate its localization, abundance, and modifications in various cellular contexts.

This antibody exhibits exceptional sensitivity and specificity, allowing for accurate and reproducible results in a wide range of applications, including immunofluorescence, immunohistochemistry, and western blotting. It has been extensively validated and tested in multiple experimental systems, ensuring its suitability for diverse research needs.

The Histone H2A.Z Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The antibody is produced using high-quality materials and undergoes stringent quality control procedures to ensure batch-to-batch consistency and reliability.

In summary, the Histone H2A.Z Polyclonal Antibody is a valuable tool for researchers studying histone modifications and chromatin dynamics. Its high specificity, sensitivity, and reliability make it an essential reagent for investigating the role of histone H2A.Z in various biological processes.