Histone H2A.Z (Acetyl Lys7) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

The Histone H2A.Z (Acetyl Lys7) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Histone H2A.Z protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the acetylated Lysine 7 residue of Histone H2A.Z.

Histone H2A.Z is a variant of the core histone protein H2A, which plays a crucial role in chromatin remodeling and gene expression regulation. The acetylation of Lysine 7 on Histone H2A.Z has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the detection and quantification of acetylated Histone H2A.Z can provide valuable insights into the epigenetic regulation of gene expression.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits high sensitivity and specificity, enabling accurate and reliable detection of acetylated Histone H2A.Z in complex biological samples.

The Histone H2A.Z (Acetyl Lys7) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing wastage. The antibody is manufactured under strict quality control standards, guaranteeing consistent and reproducible results.

In summary, the Histone H2A.Z (Acetyl Lys7) Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of acetylated Histone H2A.Z. Its high specificity, sensitivity, and versatility make it an ideal choice for researchers studying epigenetic modifications and gene expression regulation.