Histone H2A.Z (Acetyl Lys4) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

The Histone H2A.Z (Acetyl Lys4) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Histone H2A.Z protein acetylated at Lysine 4. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

Histone H2A.Z is a variant of the core histone H2A, which plays a crucial role in chromatin remodeling and gene expression regulation. Acetylation of Lysine 4 on Histone H2A.Z has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify this modification is of great importance in understanding the underlying mechanisms of these processes.

The Histone H2A.Z (Acetyl Lys4) Polyclonal Antibody exhibits exceptional sensitivity and selectivity, enabling precise detection of Histone H2A.Z acetylated at Lysine 4 in various sample types, including cell lysates and tissue extracts. It has been extensively validated for use in Western blotting, immunoprecipitation, and immunofluorescence applications.

With its superior performance characteristics, this antibody offers researchers a valuable tool for investigating the role of Histone H2A.Z acetylation in various biological processes and disease states. Its high specificity and sensitivity ensure reliable and reproducible results, making it an essential component of any study involving Histone H2A.Z acetylation.

The Histone H2A.Z (Acetyl Lys4) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows. It is provided in a liquid formulation, ensuring stability and ease of use. Each batch of antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the Histone H2A.Z (Acetyl Lys4) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Histone H2A.Z protein acetylated at Lysine 4. Its exceptional sensitivity and selectivity make it an invaluable asset for researchers studying chromatin remodeling, gene expression regulation, and various biological processes.