Histone H2A.X Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. H2AFX encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

The Histone H2A.X Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Histone H2A.X protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and quality.

Histone H2A.X is a variant of the histone H2A family and plays a crucial role in DNA damage response and repair. It is phosphorylated at serine 139 (γH2A.X) in response to DNA double-strand breaks, making it an important marker for DNA damage. The Histone H2A.X Polyclonal Antibody recognizes both the phosphorylated and non-phosphorylated forms of Histone H2A.X, allowing for comprehensive analysis of its expression and localization.

This antibody has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent specificity and sensitivity, enabling accurate and reliable detection of Histone H2A.X in a wide range of sample types, including cell lysates, tissue sections, and whole-cell extracts.

The Histone H2A.X Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 µg. It is provided in a ready-to-use format, eliminating the need for additional reagents or preparation. The antibody is stored at -20°C, ensuring long-term stability and preserving its functionality.

In summary, the Histone H2A.X Polyclonal Antibody is a valuable tool for researchers studying DNA damage response and repair. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in molecular biology, cancer research, and genomics.