Histone H1 (Di Methyl Lys25) Polyclonal Antibody

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. HIST1H1A is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from HIST1H1A lack polyA tails but instead contain a palindromic termination element. HIST1H1A is found in the large histone gene cluster on chromosome 6.

The Histone H1 (Di Methyl Lys25) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Histone H1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the Di Methyl Lys25 region of Histone H1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Histone H1 (Di Methyl Lys25) Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting Histone H1 protein.

This antibody is an essential tool for researchers studying epigenetics, chromatin structure, and gene regulation. Its high specificity and sensitivity make it an ideal choice for detecting Histone H1 protein in various biological samples. With its reliable performance and consistent results, the Histone H1 (Di Methyl Lys25) Polyclonal Antibody is a valuable addition to any research laboratory.