HisRS Polyclonal Antibody

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Histidine--tRNA ligase cytoplasmic encoded by HARS is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for HARS.

The HisRS Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of Histidyl-tRNA synthetase (HisRS) protein. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of the HisRS protein. The resulting polyclonal antibody has been purified and validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The HisRS Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of HisRS protein in various biological systems. It has been shown to detect HisRS protein in a variety of tissues and cell types, making it a versatile reagent for use in a wide range of research applications. Additionally, this antibody has been shown to exhibit minimal cross-reactivity with other proteins, ensuring high specificity and accuracy in experimental results.

Overall, the HisRS Polyclonal Antibody is a reliable and effective tool for the detection and analysis of HisRS protein in biological samples. Its high sensitivity, specificity, and versatility make it an ideal choice for researchers working in a variety of fields, including molecular biology, biochemistry, and cell biology.