HDAC5/9 Polyclonal Antibody

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 5 encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. HDAC5 is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for HDAC5.

The HDAC5/9 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of HDAC5 and HDAC9 proteins. This antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

HDAC5 and HDAC9 are members of the histone deacetylase (HDAC) family, which play crucial roles in the regulation of gene expression and chromatin remodeling. Dysregulation of HDAC5 and HDAC9 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

The HDAC5/9 Polyclonal Antibody has been developed using high-quality immunogens and advanced purification techniques to ensure superior specificity and sensitivity. It exhibits minimal cross-reactivity with other HDAC family members, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, making it easy to use and compatible with a wide range of experimental protocols. It has been validated for use in multiple species, including human, mouse, and rat, allowing for versatile applications in various research settings.

With its exceptional performance and reliability, the HDAC5/9 Polyclonal Antibody is an indispensable tool for researchers studying the role of HDAC5 and HDAC9 in cellular processes and disease mechanisms.