Glut4 Polyclonal Antibody

GLUT3 (SLC2A3) belongs to the glucose transporter family (GLUTs) which mediates the transport of glucose across cellular membranes in mammalian cells. There are three subclasses within GLUTs: class I comprises the classical transporters GLUT1-4 and GLUT14; class II contains the "odd" isoforms GLUT5, 7, 9, and 11; the isoforms GLUT6, 8, 10, 12 and the proton driven myoinositol transporter HMIT (GLUT13) belong to class III. GLUT3 is considered as a neuron-specific glucose transporter because of its dominant expression in the brain in various species. However, besides the brain GLUT3 is also expressed in tissues with high demand for glucose such as sperm, preimplantation embryos, circulating white blood cells, and an array of carcinoma cell lines. ecently GLUT3 has been identified as a sensitive and specific marker for embyonal carcinomas and yolk tumors. he GLUT14 is believed to be the duplicate gene of GLUT3 given to the high identity in sequence between them. This antibody was generated against the internal region of human GLUT3 and may cross-react with GLUT14.

The Glut4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Glut4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Glut4 protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Glut4 Polyclonal Antibody is a valuable tool for researchers studying glucose metabolism and insulin signaling pathways. Glut4 is a glucose transporter protein that plays a critical role in glucose uptake and utilization in insulin-sensitive tissues such as skeletal muscle and adipose tissue. Dysregulation of Glut4 expression and function has been implicated in various metabolic disorders, including diabetes and obesity.

This antibody is supplied as a purified IgG fraction, which has been affinity-purified using immobilized protein A. The antibody is provided in a liquid format and can be stored at -20°C for long-term storage. The Glut4 Polyclonal Antibody is available in various sizes to meet the needs of different research applications.

In summary, the Glut4 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of Glut4 protein in various biological samples. This antibody is a valuable tool for researchers studying glucose metabolism and insulin signaling pathways and can be used in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.