GluR-Delta2 Polyclonal Antibody

The glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

The GluR-Delta2 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of GluR-Delta2 protein expression in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance and accuracy in a wide range of applications, including immunohistochemistry, western blotting, and immunofluorescence.

The GluR-Delta2 Polyclonal Antibody exhibits a high affinity and selectivity towards GluR-Delta2, a subunit of the glutamate receptor family that plays a crucial role in synaptic plasticity and neuronal development. With its exceptional sensitivity, this antibody enables the precise identification and quantification of GluR-Delta2 expression levels, facilitating comprehensive investigations into the functional significance of this protein in various physiological and pathological processes.

This antibody has been rigorously tested and validated using a variety of experimental approaches, ensuring its reliability and reproducibility. It exhibits minimal cross-reactivity with other glutamate receptor subunits, guaranteeing specific and accurate detection of GluR-Delta2. Furthermore, it demonstrates excellent performance in various sample types, including tissue sections, cell lysates, and cultured cells.

The GluR-Delta2 Polyclonal Antibody is supplied as a highly purified and concentrated solution, ensuring optimal performance and ease of use. It is provided in a convenient format, allowing for flexible and efficient experimental design. Additionally, this antibody is compatible with a wide range of detection systems and can be used in combination with other antibodies for multiplex analysis.

In summary, the GluR-Delta2 Polyclonal Antibody is a valuable tool for researchers studying the role of GluR-Delta2 in synaptic plasticity, neuronal development, and related processes. Its exceptional specificity, sensitivity, and reliability make it an indispensable asset for a wide range of applications in the field of neuroscience and beyond.