GLCNE Polyclonal Antibody

The glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase encoded by GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

The GLCNE Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of GLCNE protein in various biological samples. This antibody has been produced using a purified recombinant GLCNE protein as an immunogen, and has been extensively validated for its specificity and sensitivity in various applications such as Western blotting, immunohistochemistry, and ELISA.

The GLCNE Polyclonal Antibody is a rabbit polyclonal antibody that has been purified using protein A affinity chromatography. This antibody has been shown to specifically recognize the GLCNE protein, and does not cross-react with other proteins in the same family. The antibody has been validated for its specificity using various techniques such as siRNA knockdown, overexpression, and immunoprecipitation.

The GLCNE Polyclonal Antibody is suitable for use in various applications such as Western blotting, immunohistochemistry, and ELISA. This antibody has been shown to detect endogenous levels of GLCNE protein in various cell lines and tissues, and can be used to study the expression and function of GLCNE in various biological processes.

In summary, the GLCNE Polyclonal Antibody is a highly specific and sensitive antibody that has been extensively validated for its specificity and sensitivity in various applications. This antibody is suitable for use in various research applications related to GLCNE protein, and can provide valuable insights into the expression and function of this protein in various biological processes.