GABAA R Alpha4 Polyclonal Antibody

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. GABRA4 encodes Gamma-aminobutyric acid receptor subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in GABRA4.

The GABAA R Alpha4 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of GABAA receptor alpha4 subunit. This antibody has been extensively validated for its exceptional sensitivity and specificity in various applications, including immunohistochemistry, western blotting, and immunofluorescence.

The GABAA receptor alpha4 subunit plays a crucial role in the modulation of inhibitory neurotransmission in the central nervous system. It is involved in the regulation of neuronal excitability and synaptic transmission, making it an important target for research in neuroscience and neuropharmacology.

This polyclonal antibody has been meticulously developed using advanced techniques to ensure its high affinity and selectivity towards the GABAA receptor alpha4 subunit. It exhibits minimal cross-reactivity with other GABAA receptor subunits, ensuring accurate and reliable results.

With its exceptional sensitivity, this antibody allows for the detection of even low levels of GABAA receptor alpha4 subunit expression in various tissues and cell types. Its robust performance and reproducibility make it an ideal choice for both qualitative and quantitative analysis.

The GABAA R Alpha4 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. Each batch of this antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the GABAA R Alpha4 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of GABAA receptor alpha4 subunit. Its exceptional sensitivity, selectivity, and robust performance make it an invaluable asset for researchers in the field of neuroscience and neuropharmacology.