Frizzled-7 Polyclonal Antibody

Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-7 contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

The Frizzled-7 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Frizzled-7 protein expression in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards Frizzled-7.

Frizzled-7 is a member of the Frizzled family of proteins, which are crucial components of the Wnt signaling pathway. This pathway plays a vital role in various cellular processes, including embryonic development, tissue homeostasis, and cell proliferation. Dysregulation of the Wnt signaling pathway, particularly Frizzled-7, has been implicated in numerous diseases, including cancer and developmental disorders.

The Frizzled-7 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of Frizzled-7 protein expression in both normal and diseased tissues.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The Frizzled-7 Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

With its exceptional performance and reliability, the Frizzled-7 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of Frizzled-7 in various biological processes and diseases. Its high specificity and sensitivity make it an ideal choice for accurate and precise detection of Frizzled-7 protein expression, facilitating a deeper understanding of the Wnt signaling pathway and its implications in human health and disease.