Flt3 Polyclonal Antibody

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

The FLT3 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of FLT3 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human FLT3 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards FLT3 protein, making it an ideal tool for various research applications.

The FLT3 Polyclonal Antibody is suitable for use in a variety of techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its ability to detect FLT3 protein expression in human and mouse tissues, as well as in cell lines and other biological samples. This antibody is also highly sensitive, allowing for the detection of even low levels of FLT3 protein expression.

In addition to its high specificity and sensitivity, the FLT3 Polyclonal Antibody is also highly reproducible, ensuring consistent results across multiple experiments. It is supplied in a convenient format, with ample quantities available for multiple applications. This antibody is an essential tool for researchers studying FLT3 protein expression and its role in various biological processes, including hematopoiesis and cancer.