Flk-1 Polyclonal Antibody

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR encodes one of the two receptors of the VEGF. Vascular endothelial growth factor receptor 2, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.

The Flk-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Flk-1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

Flk-1, also known as vascular endothelial growth factor receptor 2 (VEGFR2), plays a crucial role in angiogenesis and vasculogenesis processes. It is a transmembrane receptor tyrosine kinase that is primarily expressed on endothelial cells. The Flk-1 Polyclonal Antibody recognizes the extracellular domain of Flk-1, allowing for the detection of both the full-length and cleaved forms of the protein.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The Flk-1 Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size and quantity, allowing for multiple experiments without the need for frequent reordering.

With its exceptional sensitivity and specificity, the Flk-1 Polyclonal Antibody is an indispensable tool for researchers studying angiogenesis, vasculogenesis, and related processes. Its reliable performance and ease of use make it an ideal choice for both basic research and clinical applications.