Filamin 1 Polyclonal Antibody

Filamin-A encoded by FLNA is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. Filamin-A is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. Filamin-A interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in FLNA are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

The Filamin 1 Polyclonal Antibody is a highly reliable and efficient tool designed for the detection and analysis of Filamin 1 protein in various biological samples. This antibody is produced using advanced techniques and high-quality materials to ensure exceptional specificity and sensitivity.

Filamin 1 is a cytoskeletal protein that plays a crucial role in cell adhesion, migration, and signaling pathways. It is involved in the organization and stabilization of the actin cytoskeleton, contributing to the maintenance of cellular structure and integrity. Dysregulation of Filamin 1 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions.

The Filamin 1 Polyclonal Antibody has been extensively validated for its performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It exhibits a strong affinity towards Filamin 1, enabling accurate and specific detection of the protein in both cultured cells and tissue sections.

This antibody demonstrates exceptional sensitivity, allowing for the detection of low levels of Filamin 1 expression. Its high specificity ensures minimal cross-reactivity with other proteins, resulting in reliable and reproducible results. Additionally, the antibody exhibits excellent stability, enabling long-term storage without compromising its performance.

The Filamin 1 Polyclonal Antibody is supplied in a convenient and user-friendly format, making it suitable for a wide range of research applications. It is compatible with various detection systems and can be used in combination with other antibodies for multiplex staining experiments. Each batch of the antibody undergoes rigorous quality control procedures to ensure consistent and reliable performance.

In summary, the Filamin 1 Polyclonal Antibody is a valuable tool for researchers studying the role of Filamin 1 in cellular processes and disease mechanisms. Its exceptional specificity, sensitivity, and stability make it an ideal choice for accurate and reliable detection of Filamin 1 protein in various experimental settings.