Fibulin-5 Polyclonal Antibody

Fibulin-5 encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

The Fibulin-5 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Fibulin-5 protein in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards Fibulin-5.

Fibulin-5 is a crucial extracellular matrix protein that plays a significant role in various physiological processes, including tissue development, cell adhesion, and elasticity. Dysregulation of Fibulin-5 has been implicated in several pathological conditions, such as cardiovascular diseases, cancer, and connective tissue disorders. Therefore, the accurate detection and quantification of Fibulin-5 protein are of utmost importance in both research and clinical settings.

The Fibulin-5 Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both native and denatured forms of Fibulin-5, allowing for comprehensive analysis of protein expression and localization in different tissue types and cell lines.

This antibody is produced using state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. It has been extensively validated for its specificity, sensitivity, and reliability, making it an ideal choice for researchers and clinicians working in the field of Fibulin-5 biology.

In summary, the Fibulin-5 Polyclonal Antibody is a highly reliable and efficient tool for the detection and analysis of Fibulin-5 protein. Its exceptional performance, specificity, and sensitivity make it an invaluable asset in various research and clinical applications.