Factor XIII B Polyclonal Antibody

F13B encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

The Factor XIII B Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of Factor XIII B in various biological samples. This antibody is produced through a rigorous process of immunization using purified Factor XIII B protein, ensuring high affinity and specificity.

The Factor XIII B Polyclonal Antibody exhibits exceptional sensitivity, allowing for the detection of even low levels of Factor XIII B in complex biological matrices. It is suitable for use in a wide range of applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA).

This antibody is manufactured under strict quality control standards to ensure consistent and reproducible results. It has been extensively validated and characterized to guarantee its performance and reliability.

The Factor XIII B Polyclonal Antibody is supplied as a liquid formulation, making it convenient and easy to use. It is provided in a vial with an optimized concentration, allowing for efficient and cost-effective experiments.

With its exceptional specificity, sensitivity, and reliability, the Factor XIII B Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of Factor XIII B in various biological processes.